apurinic sites

apurinic sites
Sites in DNA from which purines have been lost by cleavage of the deoxy-ribose N-glycosidic linkage.

Dictionary of molecular biology. 2004.

Look at other dictionaries:

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  • APEX1 — APEX nuclease (multifunctional DNA repair enzyme) 1, also known as APEX1, is a human gene. PBB Summary section title = summary text = Apurinic/apyrimidinic (AP) sites (also called abasic sites ) occur frequently in DNA molecules by spontaneous… …   Wikipedia

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  • Mutagenesis — (pronounced /mjuːtəˈdʒɛnɪsɪs/) is a process by which the genetic information of an organism is changed in a stable manner, resulting in a mutation. It may occur spontaneously in nature, or as a result of exposure to mutagens. It can also be… …   Wikipedia

  • Site AP — Un site AP est un emplacement de l ADN où la base (normalement attachée) est manquante.En l absence de réparation, il peuvent mener à une rupture simple brin. Lors de la réplication, ils mènent très souvent à une mutation. Un site AP (site… …   Wikipédia en Français

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  • Flap structure-specific endonuclease 1 — Flap structure specific endonuclease 1, also known as FEN1, is a human gene.cite web | title = Entrez Gene: FEN1 flap structure specific endonuclease 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2237|… …   Wikipedia

  • LIG1 — Ligase I, DNA, ATP dependent, also known as LIG1, is a human gene. PBB Summary section title = summary text = LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA… …   Wikipedia

  • AP site — An AP site (meaning apurinic and apyrimidinic) is a location in DNA that have neither a purine nor pyrimidine base, usually due to DNA damage.If left unrepaired AP sites can lead to mutation during semiconservative replication as a random… …   Wikipedia

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